At HAVA Aesthetics in Esher, Surrey, we specialise in regenerative aesthetic treatments that is enhance natural beauty and long-term skin rejuvenation. One of the most requested treatments in our clinic is Polynucleotides, a next-generation injectable treatment designed to restore skin hydration, firmness, and radiance from within.
If you’re considering this professional treatment, you may be wondering, how long do polynucleotides last, when results become visible, and what affects their longevity. In this guide, Dr Hadeel Nimaa explains what to expect before and after treatment, how long your results typically last, and how to maintain beautifully refreshed, youthful skin.
Understanding Polynucleotides
Polynucleotides are biostimulatory molecules derived from DNA fragments, often extracted from purified and sterile salmon DNA due to its excellent compatibility with human tissue. These chains of nucleotides act as the building blocks of cellular repair, helping to improve cell turnover, boost collagen production, and restore the skin’s natural structure.
Unlike dermal fillers, which add volume instantly, polynucleotides treatment works gradually to regenerate the skin from within. By activating fibroblasts, improving oxygen supply, and encouraging tissue renewal, the treatment enhances skin texture, firmness, and elasticity over time. The result is stronger, healthier, and smoother skin with minimal side effects and a natural glow that continues to develop weeks after treatment.
How Long Do Polynucleotides Last?
Results from Polynucleotide injections generally last between six and twelve months, depending on your skin goals, age, and lifestyle. Because polynucleotides work by stimulating your body’s own collagen production and cell regeneration, results are long-lasting and continue to improve over time rather than fading suddenly.
Most patients notice visible improvement around three to six weeks after treatment, as collagen and elastin fibres rebuild within the skin. You’ll begin to see subtle softening of fine lines, reduction in under-eye concerns like dark circles, and better overall hydration and luminosity.
For optimal and long-lasting skin repair, Dr Hadeel Nimaa typically recommends a personalised treatment plan of two to three sessions, spaced about four weeks apart. After completing your course, maintenance sessions every six to twelve months help sustain results and support ongoing skin rejuvenation.
Why Results Vary Between Patients
Each person’s skin is unique, and results can vary based on several factors:
- Age and skin condition: Patients with more youthful skin or higher baseline collagen levels may experience longer-lasting results.
- Lifestyle habits: Smoking, poor hydration, or frequent sun exposure can slow down collagen renewal and reduce longevity.
- Skincare routine: Using medical-grade skin care products, SPF, and hydrating serums can extend your results.
- Treatment area: Polynucleotides used on the under-eye area, neck, or jawline may last differently compared to facial applications.
Because results depend on your skin’s natural regenerative cycle, Dr Hadeel Nimaa tailors every professional treatment to your specific aesthetic goals and skin type, ensuring results that feel both authentic and long-lasting.
What to Expect After Treatment
Immediately after your polynucleotides treatment, you may notice mild redness or swelling, a completely normal response that indicates the start of tissue regeneration. These signs typically subside within 24 hours, allowing for a quick recovery and minimal downtime.
In the following weeks after treatment, your skin will gradually appear smoother, firmer, and more hydrated. You may notice visible improvements in acne-related redness, loss of volume, and deeper lines, along with a reduction in tired-looking eyes or dullness.
Results continue to evolve for several months, with maximum improvement usually visible around three months post-treatment. The regenerative benefits last even longer with consistent care and maintenance.
How to Maintain and Extend Your Results
To make the most of your polynucleotides injections and maintain long-term results, aftercare is essential. Follow these simple steps to keep your skin condition at its best:
- Protect your skin from UV exposure
Daily use of SPF prevents sun damage, which can accelerate collagen breakdown and shorten your results. - Maintain skin hydration
Drink plenty of water and use nourishing serums to help your skin retain moisture and elasticity. - Follow your post-care routine
Avoid active ingredients or exfoliants for a few days and stick to gentle, hydrating skincare to allow your skin to recover. - Schedule maintenance sessions
Top-up sessions every six to twelve months will keep skin regeneration active and preserve your results. - Live a skin-healthy lifestyle
A balanced diet, quality sleep, and consistent skincare routine will support overall skin health and help results last longer.
Combining Polynucleotides with Other Treatments
To further enhance your results, Polynucleotides can be safely combined with other cosmetic treatments such as microneedling, chemical peels, or skin boosters. These complementary approaches amplify skin rejuvenation, improve tone, and target a wide range of skin concerns, from fine lines and wrinkles to hyperpigmentation and sensitive skin.
For patients addressing under-eye circles, neck laxity, or early signs of ageing, combining polynucleotide skin boosters with tear trough treatment or other non-surgical options can produce even more dramatic benefits. Dr Hadeel Nimaa, a trusted specialist in regenerative aesthetics, will design your personalised treatment plan based on your specific needs and desired results.
Why Choose HAVA Aesthetics
At HAVA Aesthetics, every treatment is led by Dr Hadeel Nimaa, a medical aesthetics specialist with extensive experience in cosmetic injectable treatments and skin regeneration. We focus on subtle, restorative results using medical-grade products and evidence-based protocols to achieve optimal skin outcomes.
Whether you’re addressing fine lines, uneven skin tone, or under-eye concerns, our approach combines precision, safety, and artistry to deliver radiant, youthful skin with minimal side effects.
Book Your Consultation with Dr. Hadeel Nimaa
If you’ve been wondering how long do polynucleotides last, our expert team at HAVA Aesthetics can guide you through every stage of your rejuvenation journey.
Contact us today to book your consultation with Dr Hadeel Nimaa and experience the long-lasting benefits of polynucleotides treatment, the advanced injectable designed to renew, repair, and revitalise your skin from within.
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