How Long Do Polynucleotides Take to Work?

Polynucleotide treatments are making waves in modern aesthetics, and for good reason. Known for their regenerative properties and ability to improve skin quality over time, these injectable skin boosters offer a different kind of result to dermal fillers or anti-wrinkle injections. But one of the most common questions patients ask is: how long do polynucleotides take to work?

At HAVA Aesthetics in Esher, Surrey, Dr Hadeel Nimaa offers expert-led treatment plans using Polynucleotide injections to target a range of skin concerns, from fine lines and skin texture to dark circles and tissue repair. If you are considering this natural, collagen-supporting option, here is what you need to know about the results timeline, what to expect at each stage, and how it compares to other aesthetic treatments.

What Are Polynucleotide Injections and How Do They Work?

Polynucleotides are chains of nucleotides derived from Salmon DNA, selected for their remarkable ability to support skin regeneration and cell repair. When injected into the skin, they do not act like typical volumising dermal fillers. Instead, they stimulate your body’s own collagen production, improve skin elasticity, and help regulate inflammatory responses. This makes them ideal for long-term skin rejuvenation.

These aesthetic treatments are particularly effective on delicate areas such as the under-eyes, cheeks, and neck, but can be used across a wide range of injection sites depending on your skin type and concerns.

When Will I Start to See Results?

Polynucleotide injections do not provide instant results. Unlike traditional fillers, where you may see immediate plumping, polynucleotides work gradually by enhancing your skin’s internal structure and hydration levels.

Here is a general timeline of what to expect:

• Day 1 to 3: Mild swelling or redness at the injection sites may occur, but this usually subsides quickly. Your skin may feel more hydrated or slightly firmer due to increased circulation and micro-inflammation
• Week 1 to 2: Subtle improvements in skin tone and texture may begin to appear. The area often feels smoother, with a more even look. Early signs of enhanced skin hydration are common
• Week 3 to 4: Most patients begin to see noticeable results. Improvements in fine lines, mild pigmentation, and overall brightness are more visible. Collagen production is now well underway
• Week 6 to 8: This is when the full results typically develop. Expect a visible difference in skin condition, with reduced signs of ageing, healthier structure, and a refreshed appearance that looks natural but lifted

For optimal outcomes, a course of 2 to 3 sessions is often recommended, spaced a few weeks apart. This allows the active ingredients to build up and continue supporting long-term skin regeneration.

What Skin Concerns Can Polynucleotides Improve?

Thanks to their regenerative mechanism, Polynucleotide treatments can help with a wide range of concerns:

• Fine lines and early signs of ageing
• Poor skin tone or dullness
• Dehydrated or crepey skin
• Dark circles under the eyes
• Mild laxity or loss of elasticity
• Post-treatment healing and tissue repair

Unlike volumising treatments, these injections enhance the skin condition by strengthening it from within. This makes them ideal for patients who prefer a subtle, natural look or want to complement existing dermal filler or anti-wrinkle results.

Who Is This Treatment Best For?

Polynucleotide injections are suitable for a wide range of skin types and ages, particularly those looking to:

• Improve long-term skin texture and hydration
• Prevent early signs of ageing
• Restore glow without heavy filler use
• Address concerns in sensitive areas, like the tear troughs or neck
• Boost skin resilience during seasonal or hormonal changes

At HAVA Aesthetics, Dr Hadeel Nimaa tailors each plan to your needs, ensuring the most suitable aesthetic treatment for your individual skin goals.

How Can I Support My Results?

To get the best out of your Polynucleotide treatments, it is important to follow good aftercare and support your skin health:

• Use gentle, hydrating skincare to complement healing
• Avoid excessive sun exposure and always wear SPF
• Limit alcohol and keep the body hydrated
• Skip intense workouts and facial treatments for the first 24 to 48 hours
• Consider regular maintenance every few months to prolong the results

Because this is a regenerative treatment, the better your internal health and skincare habits, the more effective your results will be.

Book Your Consultation at HAVA Aesthetics

If you are ready to experience smoother, brighter, and more elastic skin without dramatic changes or downtime, Polynucleotide injections may be right for you.

Book your consultation at HAVA Aesthetics in Esher with Dr Hadeel Nimaa to create a bespoke plan focused on healthy, natural-looking skin rejuvenation that evolves with your body over time